In 1962, Premier Louis J. Robichaud approved the plans and awarded building grants for a 40-bed hospital in the Saint-Quentin area. Construction started in August of that same year. The new facility officially opened in November 1963. It was equipped with a modern laboratory, an x-ray room, an operating room, and a delivery room.
The Religious Hospitallers of Saint Joseph managed the hospital up until 1981. Then, the hospital management was transferred to laymen.
In 1992, the Provincial Government passed a legislation transferring to government hospital corporations ownership of the seven N.B. Catholic hospitals that belonged to the Religious Hospitallers of Saint Joseph.
In 1996, plans were started to renovate health records, administration, admitting, waiting rooms, and the emergency department to facilitate the development of ambulatory care and services. In 1999, interior alteration and renovation work was completed.
Several specialized clinics were set up in the vacated premises. There are about 12 different clinics held by the hospital staff, such as physiotherapy, diabetes, pulmonary care, hypertension and nutrition; and about ten other clinics held by outside medical specialists, such as mental health, urology, internal medicine, and ophthalmology.
In the early 2000s, major exterior renovation work was done.
Over 80 health professionals and others work at the Hôtel-Dieu Saint-Joseph de Saint-Quentin.