To the delight of local residents, the Grand Falls General Hospital Inc. was founded on September 26, 1962, and the official opening took place on June 7, 1964. The Religious Hospitallers of Saint Joseph had agreed to manage it.
A new wing opened in April 1979. The expansion created space for examination rooms in the emergency department, a waiting room, and a physiotherapy department, along with new facilities for electrocardiography, the laboratory and radiology.
In 1986, the Foundation of the Friends of the Grand Falls General Hospital Inc. was created.
In 1988, the then Minister of Health and Community Services announced a major expansion project for the hospital. The project began in 1991, and an enthusiastic public attended the official opening on May 8, 1993.
In 1992, the Grand Falls General Hospital became part of the Region 4 Hospital Corporation.
In 2008, after changes in the governance of the health care system, the Grand Falls General Hospital became part of Regional Health Authority A.
In 2010, the then Minister of Health announced plans to renovate an unused area measuring about 495 square metres. The renovations were used to move the Laboratory and Diagnostic Imaging departments to more modern, spacious areas near the Emergency Department. Their former location was renovated and now houses Special Procedures. By setting up a separate unit for minor procedures it became possible to free up space in Ambulatory Care and thus increase the number of clinics offered at the hospital.